Vasopressin Receptor

Related Products

The neurohypophysial hormone arginine vasopressin (AVP) is involved in diverse functions including regulation of body fluid homeostasis, vasoconstriction, and adrenocorticotropic hormone release. These physiological effects are mediated by three subtypes of vasopressin receptors, designated V_1a, V_1b (or V₃), and V₂. They all belong to the large rhodopsin-like G-protein-coupled receptor family.

The V_1a receptor is expressed in both neuronal and non-neuronal tissues including the heart and elicits a variety of physiological effects including cell contraction and proliferation, stimulation of hepatic glycogenolysis, platelet aggregation and coagulation factor release. The V_1b receptor subtype is found predominantly in the pituitary gland where it stimulates adrenocorticotropic hormone release. Both the V_1a and V_1b AVP receptors act through a G protein alpha-subunit of the Gα_q family (αq, q11, q14, α15/16) to activate phospholipase C-β, and, thus enhance cellular IP3 and calcium levels. By contrast, the V₂ receptor subtype is localized predominantly to the kidney where it mediates the anti-diuretic effects of AVP through the heterotrimeric G protein Gs and activation of adenylyl cyclase.

Vasopressin Receptor Related Products (67):

By Effects:	Inhibitors (4) Agonists (24) Antagonists (33) Activators (2) Modulator (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-P1390A

d[Cha4]-AVP TFA	Agonist
d[Cha4]-AVP TFA is a potent and selective vasopressin (AVP) V1b receptor agonist with a K_i of 1.2 nM for human V1b receptor. d[Cha4]-AVP TFA shows more selective for V1b receptor than human V1a receptor, V2 receptor, and oxytocin receptors.

HY-146272

Vasopressin V2 receptor antagonist 1	Antagonist
Vasopressin V2 receptor antagonist 1 (Compound 4g) is a vasopressin V₂ receptor (V₂R) antagonist with a K_i of 3.8 nM. Vasopressin V2 receptor antagonist 1 can be used for autosomal dominant polycystic kidney disease (ADPKD) research.

HY-139572

Enuvaptan	Antagonist
Enuvaptan (BAY-2327949) is a vasopressin receptor antagonist and has the potential for research into renal and cardiovascular diseases.

HY-P2539

Big Endothelin-1 (1-39), porcine	Agonist
Big Endothelin-1 (1-39), porcine is the precursor of endothelin-1. Endothelin-1 (ET-1) is a potent vasopressor peptide. Big Endothelin-1 (1-39), porcine has similar pressor effects in vivo.

HY-P5006

(d(CH2)51,Tyr(Me)2,Dab5,Arg8)-Vasopressin	Antagonist
(d(CH2)51,Tyr(Me)2,Dab5,Arg8)-Vasopressin (d(CH2)5[Tyr(Me)2, Dab5]AVP) is a specific antagonist of vasopressin V_1a receptor, with a pA₂ of 6.71.

HY-P5535

Invopressin
Invopressin (Compound 42) is a vasopressin V1A receptor partial agonist (EC₅₀: 1.0 nM). Invopressin can be used for research of cirrhosis, including bacterial peritonitis, HRS2 and refractory ascites.

HY-P5214

Vasopressin Dimer (anti-parallel) (TFA)	Activator
Vasopressin Dimer (anti-parallel) TFA is an anti-parallel dimer of Vasopressin (HY-B1811). Vasopressin Dimer (anti-parallel) TFA can activate four G protein-coupled receptors, V1aR, V1bR, V2R, and OTR.

HY-162118

RGH-122
RGH-122 (compound 43) is an orally active, potent, selective, and hV1a receptor antagonist with K_i value of 0.3 nM and IC₅₀ of 0.9 nM. RGH-122 showes microsomal stability with CL_int value of 13/28/25 μL/min/mg.

HY-P4012

[Asu1,6-Arg8]Vasopressin	Agonist
[Asu1,6-Arg8]Vasopressin is an vasopressin agonist which potentiates cyclic AMP accumulation and ACTH release induced by corticotropin-releasing factor (CRF) in rat anterior pituitary cells in culture.

HY-P0041

F992	Inhibitor
F992 is an antidiuretic peptide and vasopressin (antidiuretic hormone) analogue.

HY-P3213

Dp[Tyr(methyl)2,Arg8]-Vasopressin	Antagonist
Dp[Tyr(methyl)2,Arg8]-Vasopressin is a non-selective peptide arginine vasopressin Vlb receptor antagonist.

HY-W104304

2-(3-Trifluoromethylphenyl)glycine hydrochloride	Antagonist
2-(3-Trifluoromethylphenyl)glycine hydrochloride is a precursor of substituted 2-acetamido-5-aryl-l, 2,4-triazolones. Substituted 2-acetamido-5-aryl-l, 2,4-triazolones are dual V1a/V2 receptor antagonists and can be used in cardiovascular disease research.

HY-P5010

(D-Arg8)-Inotocin	Antagonist
(D-Arg8)-Inotocin is a potent, selective and competitive antagonist of vasopressin receptor (V_1aR), with a K_i of 1.3 nM. (D-Arg8)-Inotocin shows more than 3000-fold selectivity for the human V1aR over the other three subtypes, OTR, V1bR and V2R.

HY-P1163

D[LEU4,LYS8]-VP	Agonist
D[LEU4,LYS8]-VP is a selective agonist of vasopressin V_1b receptor, with the K_is of 0.16 nM, 0.52 nM, and 0.1.38 nM for rat, human and mouse V_1b receptor, respectively. D[LEU4,LYS8]-VP has weak antidiuretic, vasopressor, and in vitro oxytocic activities.

HY-P4678A

(Phe2,Orn8)-Oxytocin acetate	Agonist
(Phe2,Orn8)-Oxytocin acetate is a selective V1 vasopressin agonist. (Phe2,Orn8)-Oxytocin acetate induces a sustained contractility of rabbit epididymis with EC₅₀ value of 280 nM.

HY-N12638

Endolide F	Antagonist
Endolide F (Compound 2) is a proline-containing lactone. Endolide F is a moderate antagonist of the arginine antidiuretic hormone V1A receptor.

HY-W539944

Argipressin acetate	Agonist
Argipressin (Arg8-vasopressin) (acetate) binds to the V1, V2, V3-vascular arginine vasopressin receptor, with a K_d value of 1.31 nM in A7r5 rat aortic smooth muscle cells for V1.

HY-157220

Tolvaptan phosphate ester sodium	Antagonist
Tolvaptan phosphate ester sodium, a prodrug of Tolvaptan (HY-17000), can be used in the study of cardiac edema. Tolvaptan is a selective, competitive and orally active vasopressin receptor 2 (V2R) antagonist with an IC50 of 1.28 μM for the inhibition of arginine vasopressin (AVP)-induced platelet aggregation.

HY-P1185A

Antagonist G TFA	Antagonist
Antagonist G TFA is a potent vasopressin antagonist. Antagonist G is also a weak antagonist of GRP and Bradykinin. Antagonist G induces AP-1 transcription and sensitizes cells to chemotherapy.

HY-P1162

(d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin	Antagonist
(d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin (SKF 100273) is a vasopressin V1 receptor selective antagonist.

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